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WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions.

Buddhi Prakash Jain¹, Shweta Pandey²

¹Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University, Motihari, Bihar, 845401, India. buddhiprakash@mgcub.ac.in.

The Protein Journal

|August 3, 2018

Summary

This summary is machine-generated.

WD40 domains are abundant protein structures crucial for eukaryotic cellular functions. This review details their diverse roles, evolutionary conservation, and scaffold function in protein interactions.

Keywords:

Cell signalling STRIPAK Scaffold WD40 protein

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Area of Science:

Molecular Biology
Genomics
Evolutionary Biology

Background:

WD40 domains are prevalent in eukaryotic genomes, forming β-propeller structures.
These domains facilitate protein-protein interactions, assembling into complexes like signalosomes.
WD40 proteins are implicated in fundamental cellular processes across eukaryotes.

Purpose of the Study:

To review the diverse functions of WD40 domain-containing proteins.
To examine their domain organization and evolutionary conservation.
To highlight their role as scaffolds in biological regulation.

Main Methods:

Literature review of WD40 domain-containing proteins.
Analysis of domain organization and functional roles.
Comparative analysis across different organisms (prokaryotes and eukaryotes).

Main Results:

WD40 proteins are involved in growth, cell cycle, development, virulence, signal transduction, and more.
They act as scaffolds for protein-protein and protein-DNA interactions.
No intrinsic enzymatic activity has been identified for WD40 domains.

Conclusions:

WD40 domains are versatile scaffolds essential for complex biological processes.
Their functions are conserved throughout evolution, from lower eukaryotes to prokaryotes.
Understanding WD40 proteins is key to deciphering cellular regulation and signaling.