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Supramolecular Coordination Cages for Asymmetric Catalysis
Chunxia Tan1, Dandan Chu1, Xianhui Tang1
1School of Chemistry and Chemical Engineering and State Key Laboratory, of Metal, Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 5, 2018
Summary
Artificial catalysts mimic enzymes using supramolecular coordination cages. These chiral cages create asymmetric environments for enantioselective transformations, advancing catalyst design and understanding enzymatic catalysis.
Area of Science:
- Supramolecular Chemistry
- Catalysis
Background:
- Enzymes exhibit high efficiency and specificity.
- Artificial catalysts are being developed to mimic enzyme features.
- Supramolecular coordination cages offer a versatile platform for enzyme mimics due to their confined cavities and tunable building blocks.
Purpose of the Study:
- To review recent progress in supramolecular coordination cages for asymmetric catalysis.
- To provide guidance for designing sophisticated cage catalysts.
- To explore the use of chiral supramolecular coordination cages in enantioselective transformations.
Main Methods:
- Focus on supramolecular coordination cages built from non-covalent coordination bonds.
- Categorization of approaches based on the function of cages as reaction vessels.
- Integration of chirality into supramolecular coordination cages.
Main Results:
- Supramolecular coordination cages provide confined cavities for substrate recognition, transition-state stabilization, and product release.
- Chiral supramolecular coordination cages create asymmetric microenvironments.
- Three distinct approaches utilizing supramolecular coordination cages for asymmetric catalysis have been demonstrated.
Conclusions:
- Supramolecular coordination cages are promising for developing artificial enzyme mimics.
- Chirality in these cages enables enantioselective transformations.
- This field offers insights into enzymatic catalysis and provides tools for synthetic chemistry.
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