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Processed eggshell membrane powder regulates cellular functions and increase MMP-activity important in early wound
Tram T Vuong1, Sissel B Rønning1, Tamer A E Ahmed2,3
1Nofima AS, Ås, Norway.
Plos One
|August 7, 2018
Summary
Processed eggshell membrane powder (PEP) enhances wound healing by stimulating matrix metalloproteinase (MMP) activity. This natural biomaterial promotes early cellular events crucial for skin repair and regeneration.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Cell Biology
Background:
- Avian eggshell membrane (ESM) is a natural, abundant biomaterial with potential for wound healing applications.
- Previous studies indicated processed eggshell membrane powder (PEP) possesses anti-inflammatory properties relevant to wound care.
Purpose of the Study:
- To investigate the effects of PEP on matrix metalloproteinase (MMP) activities in vitro and in vivo.
- To evaluate PEP's impact on cellular events involved in skin wound healing.
Main Methods:
- In vitro studies using dermal fibroblast cell cultures treated with PEP.
- In vivo studies utilizing a mouse skin wound healing model with PEP application.
- Analysis of MMP activity, protein levels, cytoskeletal rearrangement, and cell proliferation.
Main Results:
- PEP treatment in vitro induced actin-cytoskeleton rearrangement, focal adhesion changes, and increased MMP-2 activation.
- Longer PEP incubation in vitro led to increased MMP-2 and its regulators (MT1-MMP, TIMP-2) and alpha-smooth muscle actin (α-SMA) production.
- In vivo, PEP increased MMP activity, MMP-2 and MMP-9 levels, and keratinocyte proliferation at wound sites.
Conclusions:
- PEP stimulates MMP activity, a key factor in wound healing.
- PEP positively influences early cellular events, including myofibroblast differentiation and cell proliferation, supporting its potential in wound healing products.
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