Related Experiment Video

Updated: Feb 6, 2026

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
04:23

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

Published on: April 21, 2023

2.3K

ThyroSeq®V2.0 Molecular Testing: A Cost-Effective Approach for the Evaluation of Indeterminate Thyroid Nodules

Ana Marcella Rivas, Aziza Nassar, Jun Zhang

    Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
    |August 8, 2018
    PubMed
    Abstract

    Insights

    ThyroSeq®V2.0 molecular testing is more cost-effective than diagnostic thyroidectomy for indeterminate thyroid nodules (Bethesda categories III and IV). This approach offers a lower average cost per nodule and per cancer case detected.

    Area of Science:

    • Endocrinology
    • Oncology
    • Molecular Diagnostics

    Background:

    • Indeterminate thyroid nodules (Bethesda III/IV) present a diagnostic challenge, with many undergoing unnecessary surgery.
    • Molecular testing aids in risk stratification, potentially reducing surgical intervention.
    • ThyroSeq®V2.0 is a molecular test for evaluating these nodules.

    Purpose of the Study:

    • To assess the cost-effectiveness of ThyroSeq®V2.0 compared to diagnostic thyroidectomy for indeterminate thyroid nodules.
    • To evaluate the economic impact of molecular testing in thyroid nodule management.

    Main Methods:

    • Retrospective review of Bethesda category III and IV nodules from January 2014 to November 2016.
    • Comparison of costs associated with ThyroSeq®V2.0 testing versus diagnostic thyroidectomy.
    • Analysis of cost per nodule evaluated and cost per cancer case detected.

    Main Results:

    • For Bethesda III nodules, ThyroSeq®V2.0 averaged $14,669/nodule vs. $23,338 for surgery; cost per cancer was $58,674 vs. $62,233.
    • For Bethesda IV nodules, ThyroSeq®V2.0 averaged $14,641/nodule vs. $24,345 for surgery; cost per cancer was $31,721 vs. $53,560.
    • ThyroSeq®V2.0 demonstrated lower costs in both evaluated categories.

    Conclusions:

    • ThyroSeq®V2.0 is a cost-effective diagnostic tool for indeterminate thyroid nodules (Bethesda III/IV).
    • Molecular testing can reduce healthcare costs associated with unnecessary thyroid surgeries.

    More Related Videos

    A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery04:42

    A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

    Published on: February 17, 2023

    1.8K
    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse04:05

    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

    Published on: October 6, 2023

    778

    Related Concept Videos

    Indeterminate Structure01:18

    Indeterminate Structure

    Indeterminate structures refer to structures where internal forces and reactions cannot be determined using only the equations of static equilibrium.  Indeterminate structures have more unknown forces and reaction forces than equations of static equilibrium that can be used to determine them. Indeterminate structures are often used in engineering to create complex, efficient, and aesthetically pleasing structures. There are various types of indeterminate structures used in engineering and...
    1.5K
    Indeterminate Products01:29

    Indeterminate Products

    Indeterminate forms also arise in the evaluation of limits involving products, particularly when one factor approaches zero while the other tends to positive or negative infinity. This situation, commonly described as a zero-times-infinity form, does not have an immediately interpretable outcome. Depending on how the factors behave relative to one another, the limit of such a product may be zero, infinite, or a finite nonzero value.Product Limits and Algebraic RewritingTo analyze limits of this...
    54
    Statically Indeterminate Problem Solving01:16

    Statically Indeterminate Problem Solving

    Statically indeterminate problems are those where statics alone can not determine the internal forces or reactions. Consider a structure comprising two cylindrical rods made of steel and brass. These rods are joined at point B and restrained by rigid supports at points A and C. Now, the reactions at points A and C and the deflection at point B are to be determined. This rod structure is classified as statically indeterminate as the structure has more supports than are necessary for maintaining...
    729
    Indeterminate Forms and L’Hôpital’s Rule01:27

    Indeterminate Forms and L’Hôpital’s Rule

    Indeterminate forms occur when evaluating limits leads to expressions that cannot be directly interpreted, such as zero divided by zero or infinity divided by infinity. These results do not describe the true behavior of a function near a given point and instead signal that additional analysis is required. L’Hôpital’s Rule provides a reliable method for resolving such ambiguities by replacing the original functions with their derivatives.Core Idea of L’Hôpital’s...
    124
    The Thyroid Gland01:23

    The Thyroid Gland

    The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
    The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
    7.7K
    Molecular Models02:00

    Molecular Models

    Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
    43.8K