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Updated: Feb 6, 2026

Applying Dynamic Strain on Thin Oxide Films Immobilized on a Pseudoelastic Nickel-Titanium Alloy
Published on: July 28, 2020
C-N Bond Formation from Allylic Alcohols via Cooperative Nickel and Titanium Catalysis
S Hadi Nazari1, Norma Tiempos-Flores2, Kelton G Forson1
1Department of Chemistry and Biochemistry , Brigham Young University , Provo , Utah 84602 , United States.
Abstract:
Amination of allylic alcohols is facilitated via cooperative catalysis. Catalytic Ti(O- i-Pr)4 is shown to dramatically increase the rate of nickel-catalyzed allylic amination, and mechanistic experiments confirm activation of the allylic alcohol by titanium. Aminations of primary and secondary allylic alcohols are demonstrated with a variety of amine nucleophiles. Diene-containing substrates also cyclize onto the nickel allyl intermediate prior to amination, generating carbocyclic amine products. This tandem process is only achieved under our cooperative catalytic system.
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