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Updated: Feb 6, 2026
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Murine Model of Intestinal Ischemia-reperfusion Injury
Published on: May 11, 2016
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Microbiome and intestinal ischemia/reperfusion injury
Yuji Nadatani1, Toshio Watanabe1, Sunao Shimada1
1Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.
Journal of Clinical Biochemistry and Nutrition
|August 9, 2018
Summary
Intestinal ischemia/reperfusion injury involves complex mechanisms. The gut microbiome, including Toll-like receptors (TLRs), oxidative stress, and nitric oxide, significantly impacts this severe condition.
Area of Science:
- Gastroenterology
- Immunology
- Microbiology
Background:
- Intestinal ischemia/reperfusion (I/R) injury is a critical condition with high mortality.
- Current treatments are limited to surgical intervention.
- Emerging evidence highlights the significant role of the intestinal microbiome in I/R injury pathogenesis.
Purpose of the Study:
- To review the current understanding of the intestinal microbiome's impact on I/R injury.
- To explore the involvement of specific molecular pathways and factors.
Main Methods:
- Literature review focusing on studies investigating the gut microbiome in I/R injury.
- Analysis of research on Toll-like receptors (TLRs), oxidative stress, and nitric oxide.
Main Results:
- The intestinal microbiome is a key player in I/R injury.
- Toll-like receptors (TLR2, TLR4) and their adaptor MyD88 are implicated.
- Oxidative stress and nitric oxide pathways are associated with bacterial activity during I/R injury.
Conclusions:
- The gut microbiome profoundly influences intestinal I/R injury.
- Understanding the interplay between microbiome, TLRs, oxidative stress, and nitric oxide is crucial for developing novel therapeutic strategies.
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