Lanthanide-doped core-shell nanoparticles as a multimodality platform for imaging and photodynamic therapy

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Materials Science

Background:

• Multimodal imaging and therapy offer synergistic advantages in diagnostics and treatment.
• Developing single-entity nanoplatforms for combined functionalities remains a challenge.

Purpose of the Study:

• To design and synthesize a novel lanthanide-doped core-shell nanostructure.
• To integrate luminescence imaging (biological window II), magnetic resonance imaging, and photodynamic antimicrobial chemotherapy into a single nanoscale entity.

Main Methods:

• Synthesis of a multi-layered core-shell nanostructure (NaYF4:Yb,Er@NaGdF4:Nd@SiO2-RB).
• Characterization of the nanostructure's optical, magnetic, and structural properties.
• Evaluation of its performance in multimodal imaging and photodynamic antimicrobial chemotherapy.

Main Results:

• Successful fabrication of a core-shell nanostructure with integrated functionalities.
• Demonstration of luminescence imaging in biological window II.
• Confirmation of magnetic resonance imaging capabilities and NIR-excited photodynamic antimicrobial efficacy.

Conclusions:

• The developed nanostructure represents a promising platform for multimodal biomedical applications.
• This single-entity approach enhances imaging and therapeutic efficiency.
• Further research could explore its clinical translation for various diseases.