Related Experiment Video

Updated: Feb 6, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

9.6K

YAP and TAZ, the conductors that orchestrate eye development, homeostasis, and disease

Jing-Yi Zhu1, Sen Lin1, Jian Ye1

  • 1Department of Ophthalmology and Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, China.

Journal of Cellular Physiology
|August 11, 2018
PubMed

Insights

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key in eye development and health. This review explores their roles in ocular tissues and diseases, suggesting therapeutic potential.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Ophthalmology

Background:

  • Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators.
  • They are key components of the Hippo signaling pathway.
  • Previous research highlighted their roles in oncology and cardiovascular disease.

Purpose of the Study:

  • To synthesize advances in YAP and TAZ function during eye development.
  • To introduce their roles in ocular tissues and diseases.
  • To highlight potential therapeutic interventions targeting YAP and TAZ.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of YAP and TAZ function across different model organisms.
  • Examination of YAP and TAZ involvement in ocular pathologies.

Main Results:

  • YAP and TAZ play pivotal roles in eye morphogenesis and homeostasis.
  • Their functions are conserved across various model organisms.
  • Dysregulation of YAP and TAZ is implicated in several eye diseases.

Conclusions:

  • YAP and TAZ are crucial regulators of eye development and maintenance.
  • Understanding their pathways offers insights into ocular disease mechanisms.
  • Targeting YAP and TAZ presents a promising therapeutic avenue for eye conditions.

More Related Videos

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

8.4K
Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases05:57

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

Published on: August 2, 2022

5.1K

Related Concept Videos

What is Homeostasis?01:16

What is Homeostasis?

Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
56.6K
pH Homeostasis01:31

pH Homeostasis

Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
19.3K
Conductors and Insulators01:19

Conductors and Insulators

Some materials may easily let electrical charges pass through them, while others obstruct their flow. The former are called conductors and the latter insulators. The atomic structures of materials determine whether they are conductors or insulators of electricity.
Most metals are conductors. Their atomic configuration is such that one or more electron(s) are loosely bound to the nucleus in each atom. Thus, a sea of mobile electrons are available in them, known as free electrons. Their easy...
10.9K
Charge on a Conductor01:26

Charge on a Conductor

An interesting property of a conductor in static equilibrium is that extra charges on the conductor end up on its outer surface, regardless of where they originate. Consider a hollow metallic conductor with a uniform surface charge density. Since the conductor itself is in electrostatic equilibrium, there should not be any electric field inside the conductor. Now, assume a Gaussian surface enclosing the hollow portion. Applying Gauss's law, the inner surface of the hollow conductor will not...
5.4K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.0K
Electric Field Inside a Conductor01:20

Electric Field Inside a Conductor

When a conductor is placed in an external electric field, the free charges in the conductor redistribute and very quickly reach electrostatic equilibrium. The resulting charge distribution and its electric field have many interesting properties, which can be investigated with the help of Gauss's law.
Suppose a piece of metal is placed near a positive charge. The free electrons in the metal are attracted to the external positive charge and migrate freely toward that region. This region then...
7.5K