Related Experiment Video
Updated: Feb 6, 2026

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells
Published on: September 8, 2010
Symmetry Breaking in the Mammalian Embryo
Hui Ting Zhang1, Takashi Hiiragi1
1European Molecular Biology Laboratory, 69117 Heidelberg, Germany;
Abstract:
We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development. Although we primarily discuss embryonic development of the mouse, as it is the best-studied mammalian model system to date, we also highlight the shared and distinct aspects between different mammalian species. Finally, we discuss how insights gained from studying mammalian development can be generalized in light of self-organization principles. With this review, we hope to highlight new perspectives in studying symmetry breaking and self-organization in multicellular systems.
More Related Videos
Related Concept Videos
Fixing Double-strand Breaks
Fixing Double-strand Breaks
Symmetry
Gauss's Law: Planar Symmetry
Symmetry in Maxwell's Equations
Gauss's Law: Spherical Symmetry

