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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Pediatric optic neuritis

Sharon S Lehman1, Judith B Lavrich2

  • 1Ophthalmology, Nemours Children's Clinic-Wilmington/AI duPont Hospital for Children, Robison D. Harley MD Endowed Chair of Pediatric Ophthalmology, Clinical Professor of Ophthalmology and Pediatrics, Assistant Dean of Faculty Affairs, Sidney Kimmel Medical College at Thomas Jefferson University, Wills Eye Hospital.

Current Opinion in Ophthalmology
|August 11, 2018
PubMed

Insights

Pediatric optic neuritis diagnosis and treatment are improving with new testing methods. Research is ongoing to better understand this condition and its long-term outcomes in children.

Area of Science:

  • Pediatric Neurology
  • Ophthalmology
  • Neuroimmunology

Background:

  • Pediatric optic neuritis diagnosis and treatment present unique challenges compared to adults.
  • Differences in presentation and prognosis, including multiple sclerosis risk, exist in pediatric cases.
  • Current clinical practices are largely based on adult studies.

Purpose of the Study:

  • To provide an update on the latest advances in pediatric optic neuritis.
  • To review current research on diagnosis, treatment, and prognosis.
  • To highlight differences between pediatric and adult optic neuritis.

Main Methods:

  • Review of limited case series and retrospective studies.
  • Analysis of emerging diagnostic modalities like optical coherence tomography and visual evoked potentials.
  • Evaluation of serologic markers such as aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies.

Main Results:

  • Pediatric optic neuritis is part of the neuroinflammatory disease spectrum.
  • New testing modalities show promise for diagnosis and prognosis.
  • Small sample sizes due to low incidence contribute to conflicting study results.

Conclusions:

  • Advances in diagnostic and serologic testing may improve pediatric optic neuritis management.
  • Better prediction of prognosis is a potential outcome of new research.
  • Prospective research is needed to validate these findings.
Abstract

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