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Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application
Giovanna Scapin1, Clinton S Potter2, Bridget Carragher2
1Department of Biochemical Engineering & Structure, Merck & Co., Inc., 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
Cell Chemical Biology
|August 14, 2018
Abstract:
We present a perspective of our view of the application of cryoelectron microscopy (cryo-EM) to structure-based drug design (SBDD). We discuss the basic needs and requirements for SBDD, the current state of cryo-EM, and the challenges that need to be overcome for this technique to reach its full potential in facilitating the process of drug discovery.

