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CXCR4-directed theranostics in oncology and inflammation
Malte Kircher1, Peter Herhaus2, Margret Schottelius3
1Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Annals of Nuclear Medicine
|August 15, 2018
Summary
This review explores targeting C-X-C motif chemokine receptor 4 (CXCR4) with positron emission tomography (PET) imaging and endoradiotherapy (ERT). These advancements show promise for diagnosing and treating various cancers and inflammatory diseases.
Area of Science:
- Biochemistry and Molecular Biology
- Oncology
- Immunology
Background:
- The C-X-C motif chemokine receptor 4 (CXCR4) plays a significant role in inflammation and cancer progression.
- Chemokines and their receptors are crucial in cellular signaling and immune responses.
- Dysregulation of CXCR4 is implicated in various pathologies, including malignancies and inflammatory disorders.
Purpose of the Study:
- To provide a concise overview of chemokine and chemokine receptor physiology and pathology.
- To review the current applications of targeting CXCR4 using positron emission tomography (PET) imaging.
- To discuss the potential of CXCR4-directed endoradiotherapy (ERT) as a novel therapeutic strategy.
Main Methods:
- Literature review focusing on CXCR4's role in disease.
- Analysis of studies utilizing radiolabeled CXCR4 ligands for PET imaging.
- Examination of research on CXCR4-targeted endoradiotherapy.
Main Results:
- CXCR4 is a key target in both hematologic and solid malignancies.
- PET imaging with radiolabeled CXCR4 ligands enables visualization of disease burden and characteristics.
- CXCR4-directed ERT presents a promising new treatment modality for various conditions.
Conclusions:
- Targeting CXCR4 offers significant potential for improved diagnostics and therapeutics.
- PET imaging provides valuable insights into CXCR4-mediated processes in disease.
- CXCR4-directed ERT represents an emerging and effective treatment option.
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