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Nogo‑B receptor in relevant carcinoma: Current achievements, challenges and aims (Review)

Yu-Kun Li1, Yuan-Jie Xie1, Dai-Chao Wu1

  • 1Department of Histology and Embryology, Clinical Anatomy and Reproductive Medicine Application Institute, University of South China, Hengyang, Hunan 421001, P.R. China.

International Journal of Oncology
|August 15, 2018
PubMed

Insights

The Nogo-B receptor (NgBR) plays diverse roles in cell functions and various diseases. This review highlights NgBR

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • The Nogo-B receptor (NgBR) interacts with Nogo-B and influences lipid homeostasis, angiogenesis, and cellular processes.
  • NgBR is expressed in various human organs and cell types, including lung, liver, kidney, and inflammatory cells.

Purpose of the Study:

  • To review the multifaceted roles of NgBR, focusing on its dual function in cancer.
  • To summarize the latest research on NgBR's suppressing and activating effects in oncogenesis.

Main Methods:

  • Literature review of existing studies on NgBR.
  • Analysis of NgBR's involvement in various physiological and pathological conditions.
  • Emphasis on NgBR's function in cancer based on current research.

Main Results:

  • NgBR influences lipid and cholesterol homeostasis, angiogenesis, N-glycosylation, epithelial-mesenchymal transition, endothelial cell chemotaxis, proliferation, and apoptosis.
  • NgBR has demonstrated both tumor-suppressing and tumor-promoting effects in cancer.
  • NgBR's roles are implicated in conditions such as fatty liver, atherosclerosis, and neurological impairment.

Conclusions:

  • NgBR exhibits complex and context-dependent functions in cancer.
  • Further research into NgBR's mechanisms and clinical implications is warranted for cancer prognosis.
  • Understanding NgBR's dual role may offer novel therapeutic strategies for human cancers.

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