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Related Experiment Video

Updated: Feb 6, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

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Published on: June 18, 2018

Cntn6 deficiency impairs allocentric navigation in mice.

Di Mu¹, Yiliang Xu¹, Tian Zhao¹

¹Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Beijing Institute for Brain Disorders, Center of Schizophrenia, Capital Medical University, Beijing, China.

Brain and Behavior

|August 15, 2018

Summary

This summary is machine-generated.

Contactin-6 (Cntn6) deficiency impacts spatial learning and memory in mice. Cntn6 mutant males show impaired learning, while females exhibit altered spatial relearning, suggesting Cntn6

Keywords:

CNTN6 Morris water maze allocentric navigation hippocampus spatial learning spatial memory

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Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

Contactin-6 (Cntn6) is a cell adhesion molecule crucial for nervous system development.
Its role in hippocampal development and spatial navigation requires further elucidation.

Purpose of the Study:

To investigate the impact of Cntn6 deficiency on allocentric navigation in a mouse model.
To determine sex-specific effects of Cntn6 on spatial learning and memory.

Main Methods:

Utilized the Morris water maze task to assess spatial learning and memory.
Recorded travel distance and escape time in wild-type and Cntn6 mutant mice (male and female).
Evaluated performance during acquisition, probe, and relearning phases.

Main Results:

Cntn6 expression is detected in the developing hippocampus, increasing from P0 to P7.
Cntn6 mutant male mice exhibited impaired spatial learning acquisition.
Female mutant mice showed mild spatial memory deficits and altered spatial relearning.

Conclusions:

Cntn6 plays a significant role in hippocampal development and spatial navigation.
Cntn6 deficiency differentially affects spatial learning and memory in male and female mice.
These findings highlight Cntn6's importance in neural circuit formation underlying spatial cognition.