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Updated: Feb 6, 2026

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM
Published on: February 11, 2022
PROPAB: Computation of Propensities and Other Properties from Segments of 3D structure of Proteins
Rifat Nawaz Ul Islam1, Chittran Roy2, Parth Sarthi Sen Gupta3
1Department of Zoology, The University of Burdwan, West Bengal, 713104, India.
Abstract:
Residues in allelic positions, in the local segment of aligned sequences of proteins show wide variations. Here, we describe PROPAB that computes the propensity tables for helix, strand and coil types from multiple 3D structure files following ab initio statistical procedure. It also classifies them in range specific and chain specific manners. It further computes percentage composition and physicochemical properties along with residues propensities. It also prepares FASTA files for different segments (helix, strand and coil) in the exact order that they follow in the sequence. Representative analyses on orthologous (homologous across species) proteins demonstrate wide segmental variations of physicochemical properties. Such variations provide insights to relate the adaptation of these proteins in a given functional constraint under diverse environmental conditions. Thus, the program finds applications in the structural and evolutionary analysis of proteins.
Availability:
PROPAB is freely available at http://sourceforge.net/projects/propab/for worldwide user.
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