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A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Structure modeling to function prediction of Uncharacterized Human Protein C15orf41

Md Shakil Ahmed¹, Md Shahjaman², Enamul Kabir³

¹Department of Statistics, University of Rajshahi, Rajshahi-6205, Bangladesh.

|August 16, 2018

Summary

Genetic mutations in the C15orf41 gene cause dyserythropoietic anemia, a disorder affecting red blood cell formation. This study characterizes the C15orf41 protein

Area of Science:

Genetics
Molecular Biology
Hematology

Background:

Dyserythropoietic anemia is a genetic disorder characterized by abnormal erythroblast morphology.
The human gene C15orf41 is implicated in the pathogenesis of this anemia.
The C15orf41 protein's function remains largely uncharacterized.

Purpose of the Study:

To functionally characterize the human C15orf41 gene and its protein product.
To investigate the structural and interaction properties of C15orf41.
To provide insights into the molecular mechanisms underlying C15orf41-related dyserythropoietic anemia.

Main Methods:

Bioinformatic analysis of the C15orf41 gene and protein sequence.
Identification of protein domains and post-translational modification (PTM) sites.
Protein-protein interaction (PPI) network analysis to identify interacting partners.

Main Results:

The C15orf41 protein possesses a Treponema Pallidum (TPD) domain and exhibits thermostability, instability, and acidic properties.
Identified PTM sites include K50 (Acetylation), T114 (Phosphorylation), and K176 (Ubiquitination).
Protein-protein interaction analysis revealed a significant interaction with human ATP binding domain 4 (ATPBD4).

Conclusions:

The C15orf41 protein plays a role in erythropoiesis and complex formation.
Understanding C15orf41's interactions and modifications is crucial for elucidating dyserythropoietic anemia.
This study provides foundational data for further research into C15orf41 function and therapeutic strategies.

Keywords:

PPI networks PTM sites Phylogenetic analysis Protein domain Uncharacterized human protein C15orf41

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