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Three Distinct Sets of Connector Hubs Integrate Human Brain Function.
Evan M Gordon1, Charles J Lynch2, Caterina Gratton3
1VISN 17 Center of Excellence for Research on Returning War Veterans, Waco, TX 76711, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX 75235, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX 76789, USA.
Cell Reports
|August 16, 2018
Summary
The brain has distinct connector hubs that manage specific networks, enabling top-down control over behavior. These hubs are not uniform but specialized for integrating different brain functions.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Brain Network Organization
Background:
- Brain function relies on control networks interacting with sensory-motor and default networks.
- Connector hubs are specialized regions that interconnect these discrete brain networks.
- Previous research treated connector hubs as a single category, overlooking individual brain variations.
Purpose of the Study:
- To investigate the nature of connector hubs by examining individual-specific regions.
- To determine if connector hubs represent a unified category or separable sets.
- To characterize the distinct roles and positions of different connector hub types.
Main Methods:
- Utilized functional magnetic resonance imaging (fMRI) data from two independent datasets.
- Identified individual-specific connector hub regions.
- Analyzed the network positions, lesion effects, and task-based engagement of identified hubs.
Main Results:
- Identified three distinct sets of connector hubs, each integrating specific brain networks.
- Demonstrated that these hub categories occupy different positions within the brain's network structure.
- Showed differential effects of hubs when artificially lesioned and differential engagement during cognitive and motor tasks.
Conclusions:
- Connector hubs are not a single category but comprise separable sets with specialized functions.
- Different connector hubs facilitate top-down control over distinct processing streams.
- This suggests a refined model of brain organization with specialized hubs for integrating control functions.
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