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Modulating functional connectivity after stroke with neurofeedback: Effect on motor deficits in a controlled
Anaïs Mottaz1, Tiffany Corbet1, Naz Doganci1
1Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospitals Geneva, Avenue de Beau-Séjour 26, 1211 Geneva, Switzerland.
Neuroimage. Clinical
|August 17, 2018
Summary
This study demonstrates that manipulating functional connectivity (FC) in stroke patients using brain-computer interfaces can improve motor function. Enhancing FC causally improves neurological function and motor performance, suggesting a new therapeutic target.
Area of Science:
- Neuroscience
- Neurology
- Rehabilitation Medicine
Background:
- Functional connectivity (FC) is widely used to study brain disorders and potential therapies.
- However, direct evidence for the causal role of FC in disease and treatment is limited.
Purpose of the Study:
- To investigate the causal role of functional connectivity (FC) in motor function after stroke.
- To determine if manipulating FC using brain-computer interface (BCI) neurofeedback can improve motor performance in chronic stroke patients.
Main Methods:
- A double-blind, controlled crossover study involving ten chronic stroke patients.
- Manipulation of ipsilesional primary motor cortex FC using BCI with visual neurofeedback.
- Comparison of motor performance during targeted FC neurofeedback versus control neurofeedback.
Main Results:
- Patients successfully increased motor cortex FC through neurofeedback.
- Motor function improved significantly more with targeted FC enhancement compared to control training.
- The degree of motor improvement was proportional to the enhancement in FC.
Conclusions:
- This study provides causal evidence that functional connectivity plays a critical role in neurological function.
- Targeting FC through neurofeedback is a viable therapeutic strategy for improving motor function in stroke survivors.
- BCI-based neurofeedback offers a promising approach for stroke rehabilitation.
Keywords:
Brain-computer interfaceEEGFC, Functional ConnectivityFMA, Fugl-Meyer AssessmentFunctional connectivityMNI, Montreal Neurological InstitudeMotor cortexSnPM, Statistical non-parametric mappingStrokeMore Related Videos
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