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Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

Soumik Dinda1, Saheli Sarkar, Prasanta Kumar Das

  • 1Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata - 700 032, India. bcpkd@iacs.res.in.

Chemical Communications (Cambridge, England)
|August 18, 2018
PubMed

Insights

This study introduces a novel cancer therapy using glucose oxidase (GOx) within self-assembled vesicles. These targeted vesicles starve cancer cells by blocking their energy supply, showing significantly higher efficiency against cancer cells.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Cancer cells exhibit altered metabolism, relying heavily on glucose.
  • Targeted therapies aim to selectively eliminate cancer cells while sparing healthy ones.
  • Nanocarriers offer potential for drug delivery and therapeutic agent encapsulation.

Purpose of the Study:

  • To develop a targeted cancer-starving therapy using glucose oxidase (GOx).
  • To investigate the efficacy of self-assembled trimesic acid based biotinylated amphiphile (TMB) vesicles for cancer treatment.
  • To evaluate the selective killing of cancer cells by GOx-loaded TMB vesicles.

Main Methods:

  • Self-assembly of trimesic acid based biotinylated amphiphile (TMB) into vesicles.
  • Encapsulation of glucose oxidase (GOx) enzyme within TMB vesicles.
  • In vitro evaluation of cell viability using cancer cell lines (HeLa, B16F10) and non-cancer cell lines (CHO, NIH3T3).

Main Results:

  • TMB vesicles successfully entrapped GOx.
  • GOx-loaded TMB vesicles demonstrated selective toxicity towards cancer cells.
  • Cancer cells showed approximately 6-fold higher sensitivity to the therapy compared to non-cancer cells.
  • The mechanism involves blocking tumor energy supply via intracellular glucose oxidation.

Conclusions:

  • Self-assembled TMB vesicles loaded with GOx represent a promising strategy for targeted cancer-starving therapy.
  • This approach offers enhanced selectivity and efficiency in eliminating cancer cells.
  • The findings highlight the potential of nanovesicle-based enzyme delivery for cancer treatment.

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