Related Experiment Video
Updated: Feb 6, 2026
06:26
Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
77.7K
Replacing Sedentary Time: Meta-analysis of Objective-Assessment Studies.
Jesús Del Pozo-Cruz1, Antonio García-Hermoso2, Rosa M Alfonso-Rosa3
1Department of Physical Education and Sports, University of Seville, Seville, Spain.
American Journal of Preventive Medicine
|August 21, 2018
Summary
Replacing sedentary time with physical activity offers health benefits. Moderate to vigorous activity shows stronger impacts on cardiometabolic risk markers and mortality than light activity.
Area of Science:
- Public Health
- Exercise Physiology
- Preventive Medicine
Background:
- Sedentary behaviors are linked to increased cardiometabolic risk and mortality.
- Understanding the benefits of replacing sedentary time with physical activity is crucial for public health guidelines.
Purpose of the Study:
- To summarize device-measured estimates of replacing sedentary time with light-intensity physical activity (LIPA) or moderate-to-vigorous physical activity (MVPA).
- To assess the impact on cardiometabolic risk markers and all-cause mortality.
Main Methods:
- Systematic review and meta-analysis of 10 studies with 17,390 participants.
- Data extracted on body mass index (BMI), waist circumference, high-density lipoprotein cholesterol (HDL-C), fasting glucose, fasting insulin, homeostatic model assessment-insulin resistance (HOMA-IR), and all-cause mortality.
- Regression coefficients and hazard ratios were analyzed.
Main Results:
- Replacing 30 minutes of sedentary time with LIPA or MVPA was associated with improved cardiometabolic markers and reduced all-cause mortality risk.
- MVPA showed stronger associations with reductions in BMI, waist circumference, fasting glucose, and fasting insulin compared to LIPA.
- Both LIPA and MVPA were linked to increased HDL-C.
Conclusions:
- Replacing sedentary time with either LIPA or MVPA yields health benefits.
- MVPA demonstrates a broader and stronger impact on cardiometabolic risk markers.
- LIPA offers a viable alternative for individuals unable to perform higher-intensity activities, including older adults.
Related Concept Videos
01:09Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
01:05Noncompartmental Analysis: Mean Residence Time
611
According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
611
01:18Velocity of an Object
207
Understanding how an object moves along a path requires distinguishing between motion over a time span and motion at a precise moment. A useful example is a vehicle traveling along a straight and level path, where its position at any given time is known. The initial step in analyzing this motion is to measure how far the vehicle travels over a fixed time period. This measurement, called average velocity, is computed by dividing the total change in position by the duration over which the change...
207
01:30Continuous Renal Replacement Therapy
1.1K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.1K
01:29Potential Due to a Polarized Object
801
A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...
801
01:24Potential Due to a Magnetized Object
816
Magnetic dipoles in magnetic materials are aligned when placed under an external magnetic field. For paramagnets and ferromagnets, dipole alignment occurs in the direction of the magnetic field. However, the dipoles align opposite to the field in the case of diamagnets. This state of magnetic polarization due to the external field is called magnetization. Magnetization is defined as the dipole moment per unit volume. It plays a similar role to polarization in electrostatics.
The vector...
The vector...
816