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Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy

Naoki Okumura1, Ryousuke Hayashi1, Noriko Koizumi1

  • 1Department of Biomedical Engineering, Faculty of Life and Medical Sciences,Doshisha University,Kyotanabe,Japan.

The Open Ophthalmology Journal
|August 21, 2018
PubMed
Abstract

Insights

Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive eye disease. New research into its genetic basis and pathophysiology suggests promising new treatments beyond corneal transplantation may soon be available.

Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive bilateral disease affecting the corneal endothelium.
  • Recent research has uncovered a novel genetic basis and elucidated the pathophysiology of FECD.
  • Historically, corneal transplantation has been the sole treatment option for FECD.

Purpose of the Study:

  • To review current knowledge on FECD genetics and pathophysiology.
  • To introduce emerging therapeutic modalities for FECD.

Main Methods:

  • Review of recent genetic studies.
  • Analysis of basic research findings on FECD pathophysiology.
  • Survey of novel therapeutic strategies.

Main Results:

  • Identification of a novel genetic basis for FECD.
  • Evidence supporting specific pathophysiological mechanisms.
  • Emergence of promising new therapeutic targets.

Conclusions:

  • Current understanding of FECD genetics and pathophysiology has advanced significantly.
  • Novel therapeutic approaches show potential to alter FECD treatment paradigms.
Keywords:
ECMEndothelial Corneal DystrophyFECDICD3SNPTCF4

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