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Updated: Feb 6, 2026

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
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Intra- and interatrial conduction abnormalities: hemodynamic and arrhythmic significance

Nicolas Johner1, Mehdi Namdar1, Dipen C Shah2

  • 1Cardiology Division, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
|August 22, 2018
PubMed

Insights

Interatrial block (IAB), a common heart rhythm disorder, indicates atrial remodeling and predicts stroke and arrhythmias. Early identification of IAB on ECGs aids risk assessment and guides potential interventions.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Internal Medicine

Background:

  • Alterations in atrial conduction are frequent in cardiovascular disease, linked to aging, risk factors, and heart conditions.
  • Interatrial block (IAB), a prevalent conduction disorder, impacts up to 20% of primary care patients.
  • IAB is characterized by prolonged P wave duration on ECG, with partial and advanced forms.

Purpose of the Study:

  • To highlight the significance of interatrial block (IAB) as a marker of atrial remodeling and a prognostic indicator.
  • To emphasize advanced IAB as an arrhythmologic syndrome associated with adverse cardiovascular outcomes.
  • To explore the implications of P wave abnormalities for identifying associated conditions and guiding therapeutic strategies.

Main Methods:

  • Analysis of electrocardiogram (ECG) findings, specifically P wave duration and morphology.
  • Review of clinical settings and patient populations where IAB is prevalent.
  • Association of IAB with cardiovascular risk factors, atrial remodeling, and clinical outcomes.

Main Results:

  • Advanced IAB is an independent risk factor for supraventricular tachyarrhythmias and embolic stroke.
  • IAB is linked to left atrial electromechanical dysfunction, atrioventricular dyssynchrony, and left ventricular diastolic dysfunction.
  • Increased P wave duration correlates with cardiovascular and all-cause mortality.

Conclusions:

  • Atrial conduction abnormalities, including IAB, signify atrial remodeling and possess prognostic value.
  • Advanced IAB represents a distinct arrhythmologic syndrome requiring clinical attention.
  • Identifying IAB prompts investigation of associated conditions, potentially allowing for upstream treatment to modify atrial remodeling or prevent adverse events.

Keywords:
Atrial fibrillationAtrial flutterConduction blockHeart failureInteratrial blockStrokeThromboembolism

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