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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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Venous Thromboembolism and Cancer
Alec A Schmaier1, Paurush Ambesh2, Umberto Campia3
1Brigham & Women's Hospital, 75 Francis St. AB378, Boston, MA, 02115, USA.
Current Cardiology Reports
|August 22, 2018
Summary
Venous thromboembolism (VTE) significantly impacts cancer patients. While new models predict VTE risk and direct oral anticoagulants (DOACs) show promise, their long-term efficacy and safety in cancer require further study.
Area of Science:
- Oncology
- Hematology
- Clinical Medicine
Background:
- Venous thromboembolism (VTE) is a serious complication in cancer patients, contributing to significant morbidity and mortality.
- Understanding the complex interplay between cancer, its treatments, and hypercoagulability is crucial for effective management.
Purpose of the Study:
- To review the epidemiology of VTE in cancer patients.
- To summarize current knowledge on the pathophysiology of cancer-associated VTE.
- To discuss the latest advancements in VTE treatment for cancer patients.
Main Methods:
- Literature review of epidemiological data.
- Synthesis of current research on cancer-related hypercoagulability mechanisms.
- Evaluation of recent treatment strategies, including direct oral anticoagulants (DOACs).
Main Results:
- VTE risk varies widely among cancer patients; new prediction models improve risk stratification.
- Novel mechanisms contributing to cancer-related hypercoagulability have been identified.
- Direct oral anticoagulants (DOACs) show promising efficacy for VTE treatment in cancer but may increase gastrointestinal bleeding risk.
Conclusions:
- The benefit/risk assessment of VTE treatment in cancer patients remains challenging.
- While DOACs offer expanded therapeutic options, comprehensive data on their long-term efficacy and safety in this population are still needed.
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