[Multi-objective Simultaneous Optimization of Huang-ma Slow-release Membrane Spray Agent]

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Dermatology

Background:

• Developing effective drug delivery systems is crucial for wound management.
• Slow-release formulations can improve therapeutic efficacy and patient compliance.
• Huang-ma (a traditional Chinese medicine) holds potential for topical applications.

Purpose of the Study:

• To optimize the material composition of Huang-ma slow-release membrane spray agent.
• To evaluate its delivery characteristics and in vitro transdermal release profile.

Main Methods:

• Utilized polyvinyl alcohol (PVA17-88), ethanol, and glycerin as factors for optimization.
• Assessed film-forming properties and release rates of strychnine and berberine hydrochloride over eight hours.
• Employed Franz diffusion cells for in vitro release and transdermal studies.

Main Results:

• Identified optimal concentrations: 5% PVA17-88, 15% ethanol, and 6% glycerin.
• The optimized Huang-ma spray exhibited favorable release characteristics and good film-forming properties.
• Demonstrated adherence to kinetic release equations over an eight-hour period.

Conclusions:

• The developed Huang-ma slow-release membrane spray is a feasible and effective drug delivery system.
• The formulation allows for even, quantitative, and slow drug release.
• The spray provides wound protection with minimal irritation, good adhesion, and flexibility.