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Porcine Model of Infrarenal Abdominal Aortic Aneurysm
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Obstructive Sleep Apnoea and Aortic Aneurysm: A Nationwide Population-Based Retrospective Study
Chang-Chih Shih1, Jen-Chun Wang1,2, Shih-Hung Tsai1
1Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Journal of Vascular Research
|August 23, 2018
Summary
Patients with obstructive sleep apnoea (OSA) do not face a higher risk of aortic aneurysm (AA). However, individuals with both COPD and OSA showed an increased AA incidence compared to those without OSA.
Area of Science:
- Cardiology
- Pulmonology
- Epidemiology
Background:
- Obstructive sleep apnoea (OSA) is a common condition.
- Aortic aneurysm (AA) is a serious vascular disease.
- The relationship between OSA and AA risk requires further investigation.
Purpose of the Study:
- To investigate the association between obstructive sleep apnoea (OSA) and the risk of developing aortic aneurysm (AA).
Main Methods:
- A nationwide population-based retrospective cohort study using the Taiwan National Health Insurance Research Database (NHIRD).
- Adult patients newly diagnosed with OSA between 2000-2010 were compared to a control cohort without OSA.
- 1:4 matching based on sex, age, index year, and comorbidities was performed. AA diagnosis was the primary outcome.
Main Results:
- No significantly increased cumulative risk of developing AA was observed in patients with OSA compared to those without.
- Male sex, older age, diabetes mellitus, COPD, and coronary artery disease were independently associated with AA occurrence.
- In the subgroup with COPD, patients with OSA exhibited a higher incidence of AA risk.
Conclusions:
- Patients with obstructive sleep apnoea (OSA) do not have an elevated risk of aortic aneurysm (AA).
- However, a subgroup analysis revealed that patients with both COPD and OSA have a higher risk of AA.
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