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Establishment of Deep Hypothermic Circulatory Arrest in Rats

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Circulatory Mechanotherapeutics: Moving with the Force.

Pablo Huang Zhang^1,2, J Yasha Kresh^3,4

¹Department of Cardiothoracic Surgery, Drexel University College of Medicine, 245 N. 15th Street, Room 6320, MS 111, Philadelphia, PA, 19102, USA.

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|August 24, 2018

Summary

Advancements in mechanical circulatory support (MCS) devices improve performance and reduce adverse events. Future designs may use spiral flow to enhance hemodynamics and vascular health, addressing current limitations.

Keywords:

Mechanical circulatory support (MCS)Mechanobiology Mechanotransduction Outflow cannula Pulsatility Spiral blood flow

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Area of Science:

Biomedical Engineering
Cardiovascular Research
Medical Device Technology

Background:

Mechanical circulatory support (MCS) devices face challenges like size, pump failure, bleeding disorders, and vascular complications.
Improvements include magnetically levitated impellers, hydrodynamic bearings, miniaturization, and reduced energy consumption in continuous flow pumps.

Purpose of the Study:

To review current advancements in mechanical circulatory support (MCS) devices.
To explore novel design considerations for future MCS, focusing on spiral flow regimes.

Main Methods:

Review of current literature on MCS device performance and adverse events.
Analysis of recent studies on fluid dynamics at the MCS outflow cannula and aorta interface.

Main Results:

Spiral flow regimes demonstrate hemodynamically beneficial attributes, reducing jet impact and organizing streamlines.
Spiral flow can improve endothelial function by modulating wall shear stress.

Conclusions:

Despite improvements, current MCS devices are not perfect.
Induced spiral fluid modulation offers a potential solution for flow-mediated disturbances in vascular mechanobiology.
Future MCS designs incorporating spiral flow may further enhance patient outcomes.