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Antigen reactive memory T cells are defined by Ta1.

D A Hafler, D A Fox, D Benjamin

Journal of Immunology (Baltimore, Md. : 1950)

|July 15, 1986

Summary

The Ta1 antigen, found on activated T cells, marks T memory cells responsible for anamnestic responses to recall antigens. This protein is crucial for immune memory but not for general T cell activation or suppression.

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Area of Science:

Immunology
Cell Biology
T cell activation and memory

Background:

Ta1 antigen is a 105,000 dalton protein expressed on a small fraction of resting human peripheral blood T cells.
It is strongly expressed on T cell clones and activated T cells, irrespective of cell cycle, unlike some growth factor receptors.

Purpose of the Study:

To investigate the function of the Ta1 antigen in human T lymphocytes.
To determine if Ta1 expression correlates with specific T cell responses, such as anamnestic responses and autologous mixed lymphocyte reactions.

Main Methods:

Separation of human peripheral blood T lymphocytes into Ta1-enriched and Ta1-depleted subpopulations.
Assessment of anamnestic responses to recall antigens (tetanus toxoid, mumps).
Evaluation of responses to mitogen (PHA) and autologous mixed lymphocyte response.
Analysis of Ig synthesis induction and suppressor cell activity.

Main Results:

The Ta1-enriched T cell subpopulation (10-15% of lymphocytes) contained most of the anamnestic response to recall antigens.
Both Ta1-enriched and -depleted cells responded equally to PHA, indicating Ta1 is not required for general mitogenic activation.
The autologous mixed lymphocyte response was higher in Ta1-enriched cells, and Ta1- cells did not exhibit suppressor activity.

Conclusions:

The Ta1 antigen serves as a marker for previously activated T cells in peripheral blood.
The Ta1+ T cell subpopulation appears to encompass T memory cells, crucial for adaptive immunity.
Ta1 expression is associated with antigen-specific memory but not general T cell activation or suppression.

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