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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Is This Organ Donor Safe?: Donor-Derived Infections in Solid Organ Transplantation

Staci A Fischer1

  • 1The Warren Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA; Accreditation Council for Graduate Medical Education, 401 North Michigan Avenue, Suite 2000, Chicago, IL 60611, USA.

Infectious Disease Clinics of North America
|August 28, 2018
PubMed

Insights

Infection transmission from organ donors is a serious risk for transplant recipients. Careful donor screening for infections, especially meningoencephalitis, is crucial to prevent severe outcomes and improve transplant success.

Area of Science:

  • Transplantation immunology
  • Infectious disease transmission
  • Public health

Background:

  • Infection is a common and serious complication following solid organ transplantation.
  • Unrecognized infections can be transmitted from deceased donors to immunosuppressed recipients.
  • Recent outbreaks highlight the risks associated with donors having meningoencephalitis.

Purpose of the Study:

  • To emphasize the critical need for caution when considering donors with potential meningoencephalitis.
  • To underscore the importance of screening organ donors for transmissible infections.
  • To improve outcomes in solid organ transplantation by mitigating infection transmission risks.

Main Methods:

  • Review of recent outbreaks of donor-derived infections.
  • Analysis of mortality and morbidity associated with transmitted infections.
  • Assessment of current screening protocols for organ donors.

Main Results:

  • Deceased donor-derived infections have led to high mortality and severe morbidity.
  • Donors with possible meningoencephalitis pose a significant transmission risk.
  • Effective screening is essential to prevent disseminated disease in transplant recipients.

Conclusions:

  • Vigilance is required when evaluating donors with suspected meningoencephalitis.
  • Comprehensive screening of organ donors for transmissible infections is paramount.
  • Implementing robust screening measures can significantly enhance transplantation outcomes and patient safety.
Keywords:
Donor-derived infectionsDonor-transmitted infectionsLymphocytic choriomeningitis virusOrgan donor screeningTransplant infections

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