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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
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Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
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Epiphytes, Parasites, and Carnivores02:40

Epiphytes, Parasites, and Carnivores

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Plants often form mutualistic relationships with soil-dwelling fungi or bacteria to enhance their roots’ nutrient uptake ability. Root-colonizing fungi (e.g., mycorrhizae) increase a plant’s root surface area, which promotes nutrient absorption. While root-colonizing, nitrogen-fixing bacteria (e.g., rhizobia) convert atmospheric nitrogen (N2) into ammonia (NH3), making nitrogen available to plants for various biological functions. For example, nitrogen is essential for the...
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Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

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A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
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Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

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The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
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Plasmodium Parasites Viewed through Proteomics.

Kristian E Swearingen1, Scott E Lindner2

  • 1Institute for Systems Biology, Seattle, WA 98109, USA; Center for Infectious Disease Research, Seattle, WA 98109, USA.

Trends in Parasitology
|August 28, 2018
PubMed
Summary
This summary is machine-generated.

Proteomics research on malaria parasites (Plasmodium) has advanced significantly, revealing key regulatory mechanisms. Future efforts should standardize data sharing for improved Plasmodium research.

Keywords:
Plasmodiummalaria parasitesmass spectrometrypost-translational modificationsproteomicsquantitative proteomics

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Area of Science:

  • Parasitology
  • Genomics
  • Proteomics

Background:

  • Genome sequencing of Plasmodium parasites has enabled transcriptomic and proteomic studies.
  • Proteomics has become a crucial tool for understanding malaria parasite biology.

Purpose of the Study:

  • To review proteomic advances in Plasmodium research over the past decade.
  • To highlight how proteomics addresses fundamental questions about parasite form and function.
  • To offer perspectives on future directions and standardization in Plasmodium proteomics.

Main Methods:

  • Global and subcellular proteomics approaches.
  • Quantitative proteomics techniques.
  • Detection and analysis of post-translational modifications.

Main Results:

  • Proteomics has elucidated critical aspects of Plasmodium parasite regulatory mechanisms.
  • Advances in instrumentation and data processing have accelerated discoveries.
  • Specific proteomic strategies have revealed important features of parasite biology.

Conclusions:

  • Proteomics is rapidly advancing our understanding of Plasmodium parasites.
  • Standardization of data deposition, analysis, and accessibility is crucial for future progress.
  • Further applications of proteomics hold significant promise for malaria research.