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[Hypothermia during Treatment with Aripiprazole]
Ralf Kozian1, Gregor Schmid1, Sergiu Demian1
1Vinzenz von Paul Hospital, Rottweil.
Psychiatrische Praxis
|August 28, 2018
Summary
Atypical neuroleptics, like aripiprazole, can cause hypothermia, a dangerous drop in body temperature. This case highlights the risk in elderly dementia patients undergoing neuroleptic treatment.
Area of Science:
- Neuroscience
- Pharmacology
- Geriatrics
Background:
- Neuroleptic medications are known to cause thermoregulation disturbances, particularly hyperthermia.
- Hypothermia, or low body temperature, is an increasingly recognized side effect of atypical neuroleptics.
- This effect is linked to serotonin 5-HT2A receptor antagonism.
Purpose of the Study:
- To report a case of hypothermia in an elderly patient treated with an atypical neuroleptic.
- To highlight the potential risk of hypothermia associated with aripiprazole in patients with dementia.
Main Methods:
- Case report of a 92-year-old patient with dementia.
- Analysis of adverse events during aripiprazole treatment.
Main Results:
- The patient experienced hypothermia while being treated with aripiprazole.
- This suggests a causal link between aripiprazole and hypothermia in this patient.
Conclusions:
- Aripiprazole, an atypical neuroleptic, can induce hypothermia.
- Elderly patients with dementia are potentially at higher risk for this adverse effect.
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