68Ga-PSMA Uptake in Angiolipoma.
Irma Dekker1, Marloes van der Leest1, Maartje C van Rijk1
1From the Departments of Radiology and Nuclear Medicine, and.
Clinical Nuclear Medicine
|August 29, 2018
Summary
Gallium-PSMA PET/CT scans can show increased uptake in lesions unrelated to prostate cancer. This case highlights angiolipoma as a potential cause of false positives in prostate cancer restaging.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
Background:
- Gallium-PSMA PET/CT is a key imaging modality for prostate cancer staging and detection.
- Increased Gallium-PSMA uptake can occur in conditions other than prostate cancer, including benign and malignant lesions.
Observation:
- A 56-year-old man with treated prostate carcinoma underwent Gallium-PSMA PET/CT for restaging.
- The scan revealed expected uptake in the prostatic bed and unexpected uptake in multiple subcutaneous lesions.
Findings:
- Histopathological examination of a subcutaneous lesion confirmed it to be an angiolipoma.
- This finding demonstrates Gallium-PSMA uptake in a benign subcutaneous tumor.
Implications:
- Awareness of non-prostate cancer-related Gallium-PSMA uptake is crucial for accurate interpretation.
- Angiolipomas should be considered in the differential diagnosis of incidental Gallium-PSMA-avid subcutaneous lesions.
- Further research is needed to understand the mechanisms of Gallium-PSMA uptake in benign conditions.
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