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[Retroviruses and the immune system]
Three examples are presented to illustrate the importance of retroviruses and associated oncogenes in neoplasms of the immune system. In adult T-cell leukemia/lymphoma the HTLV I-provirus is often integrated in the human genome on chromosome 8 adjacent to the c-myc protooncogene. Cytogenetic studies of Burkitt's lymphoma (translocation of a chromosome 8 fragment) and a case of mycosis fungoides (trisomy of chromosome 8) indicate that the same oncogene may possibly be activated not only by retroviruses, but also by chromosomal aberrations.
Three examples are presented to illustrate the importance of retroviruses and associated oncogenes in neoplasms of the immune system. In adult T-cell leukemia/lymphoma the HTLV I-provirus is often integrated in the human genome on chromosome 8 adjacent to the c-myc protooncogene. Cytogenetic studies of Burkitt's lymphoma (translocation of a chromosome 8 fragment) and a case of mycosis fungoides (trisomy of chromosome 8) indicate that the same oncogene may possibly be activated not only by retroviruses, but also by chromosomal aberrations.