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Non-coding RNAs are promising targets for stem cell-based cancer therapy
Naoya Sakamoto1, Ririno Honma1, Yohei Sekino1
1Department of Molecular Pathology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Non-Coding RNA Research
|August 31, 2018
Summary
Non-coding RNAs (ncRNAs) regulate gene expression and are crucial in stem cell biology and regenerative medicine. Understanding ncRNA interactions with tissue and cancer stem cells offers new therapeutic strategies, particularly for cancer treatment.
Area of Science:
- Molecular Biology
- Genetics
- Regenerative Medicine
Background:
- Non-coding RNAs (ncRNAs) are RNA molecules that do not encode proteins.
- ncRNAs play critical roles in regulating gene expression across physiological and developmental processes.
- Stem cells are pivotal in regenerative medicine for generating therapeutic cell types.
Purpose of the Study:
- To review recent advancements in understanding ncRNA interactions with tissue and cancer stem cells.
- To discuss the challenges and potential solutions in ncRNA research related to stem cells.
- To highlight the therapeutic potential of ncRNAs in pathological disorders, especially cancer.
Main Methods:
- Literature review of recent progress in ncRNA and stem cell research.
- Analysis of ncRNA involvement in stem cell biology, pluripotency, and differentiation.
- Exploration of in vivo modulation strategies using ncRNAs for therapeutic applications.
Main Results:
- ncRNAs are integral to the complex regulatory networks controlling gene expression in stem cells.
- Significant progress has been made in elucidating ncRNA roles in stem cell pluripotency and differentiation.
- ncRNAs show promise for in vivo therapeutic applications in treating diseases like cancer.
Conclusions:
- A deeper understanding of ncRNAs in stem cell biology is essential for advancing cancer therapy.
- ncRNA modulation offers a promising avenue for regenerative medicine and treating pathological conditions.
- Further research into ncRNA mechanisms can unlock novel therapeutic strategies for various diseases.
Keywords:
CD, cytosine deaminaseCSC, cancer stem cellEMT, epithelial to mesenchymal transitionESCs, embryonic stem cellsMET, mesenchymal to epithelial transitionMSCs, mesenchymal stem cellsNon-coding RNAStem cell-based therapyT-UCR, transcribed ultraconserved regionTranscribed ultraconserved regioniPSCs, induced pluripotent stem cellslincRNA, long inverting non-coding RNAlncRNA, long ncRNAmiRNAs, microRNAsncRNAs, non-coding RNAs
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