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Synthetic applications and methodology development of Chan-Lam coupling: a review
Iqra Munir1, Ameer Fawad Zahoor2, Nasir Rasool1
1Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Abstract:
Chan-Lam coupling is one of the most popular and easy methods to perform arylation of amines (N-arylations). This cross-coupling is generally performed by reacting aryl boronate derivatives with a variety of substrates involving nitrogen containing functional groups such as amines, amides, ureas, hydrazine, carbamates. This article summarizes the synthetic applications of this reaction and the efforts of scientists to develop novel and efficient methodologies for this reaction.
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