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3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy
Hongshi Ma1, Chun Feng1, Jiang Chang2
1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100043, People's Republic of China.
Acta Biomaterialia
|August 31, 2018
Summary
Three-dimensional (3D) printing enables advanced bioceramic scaffolds for bone regeneration and tumor therapy. These functional scaffolds offer a dual approach for healing bone defects and targeting residual cancer cells.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Oncology
Background:
- Conventional bioceramic scaffolds are primarily used in bone tissue engineering.
- Recent advancements have expanded bioceramic scaffold applications beyond traditional uses.
- Three-dimensional (3D) printing offers precise fabrication for complex scaffold structures.
Purpose of the Study:
- To review the development of 3D-printed bioceramic scaffolds.
- To explore their applications in bone tissue regeneration and bone tumor therapy.
- To highlight functional scaffolds with dual therapeutic capabilities.
Main Methods:
- Focus on 3D-printed bioceramic scaffolds with diverse compositions.
- Analysis of hierarchical structures (macro, micro, nano scales).
- Evaluation of mechanical, degradation, permeability, and biological properties.
Main Results:
- 3D-printed bioceramic scaffolds demonstrate tunable properties based on composition and structure.
- Functional scaffolds show potential for simultaneous bone defect repair and tumor cell elimination.
- Hierarchical structures influence scaffold performance in biological applications.
Conclusions:
- 3D-printed bioceramic scaffolds represent a significant advancement in personalized medicine.
- Functional scaffolds offer a novel therapeutic strategy for bone defects and residual tumor cells.
- Future research should focus on optimizing these multifunctional scaffolds for clinical translation.
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