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Updated: Feb 5, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Subthreshold Stimulation for His Bundle Pacing.

Benjamin J Scherlag1

  • 1The Department of Medicine, The Heart Rhythm Institute, The University of Oklahoma Health Sciences Center, 800 Stanton L. Young Boulevard, Suite 5400, Oklahoma City, OK 73104, USA.

Cardiac Electrophysiology Clinics
|September 3, 2018
PubMed
Summary
This summary is machine-generated.

Permanent His bundle pacing can be achieved using subthreshold stimulation. This novel approach may increase device battery life and extend replacement intervals for patients requiring cardiac pacing.

Keywords:
AtrioventricularAtrioventricular blockDirect currentHis bundle pacingLong- and short-durationSub-threshold stimulation

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Permanent His bundle pacing is a pacing technique that can lead to high pacing thresholds.
  • High pacing thresholds can reduce the longevity of implanted pacing devices.

Purpose of the Study:

  • To investigate the feasibility of achieving His bundle pacing with subthreshold stimulation.
  • To explore potential mechanisms for subthreshold stimulation effects in His bundle pacing.

Main Methods:

  • Experimental study investigating His bundle pacing thresholds.
  • Evaluation of stimulation parameters before and after atrioventricular block onset.

Main Results:

  • Preliminary evidence suggests His bundle pacing is achievable with subthreshold stimulation.
  • Subthreshold stimulation may offer a method to increase pacing device battery life.

Conclusions:

  • Subthreshold His bundle pacing presents a promising alternative to conventional pacing.
  • This approach could lead to longer replacement intervals and improved patient outcomes.