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Positively-charged hierarchical PEDOT interface with enhanced electrode kinetics for NADH-based biosensors
Lingyin Meng1, Anthony P F Turner1, Wing Cheung Mak1
1Biosensors and Bioelectronics Centre, Division of Sensor and Actuator Systems, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83 Linköping, Sweden.
Biosensors & Bioelectronics
|September 3, 2018
Summary
We developed a novel positively-charged, hierarchical micro-structured Poly(ethylenedioxythiophene) (PEDOT) electrode. This advanced material enhances electrochemical sensing of NADH, offering improved sensitivity and stability for biosensor applications.
Area of Science:
- Electrochemistry
- Materials Science
- Nanotechnology
Background:
- Poly(ethylenedioxythiophene) (PEDOT) is a promising electrode material for electrochemical sensors due to its electrical and physicochemical properties.
- Developing advanced PEDOT architectures is crucial for enhancing electrode performance in biosensing applications.
Purpose of the Study:
- To create a positively-charged, hierarchical micro-structured PEDOT electrode with improved kinetics for NADH electrooxidation.
- To investigate the impact of hierarchical structure and positive charge on electrode performance compared to conventional PEDOT:PSS.
Main Methods:
- Synthesis of processable PEDOT colloidal microparticles (PEDOT CMs) via template-assisted polymerization.
- Fabrication of hierarchically-structured electrodes using PEDOT CMs as building blocks.
- Electrochemical characterization of NADH electrooxidation using the developed electrodes.
Main Results:
- Hierarchically-structured PEDOT CMs electrodes exhibited a 2.8-fold larger accessible electroactive surface area than PEDOT:PSS.
- Improved electrode kinetics and enhanced NADH electrooxidation at lower potentials were observed.
- The PEDOT CMs electrodes demonstrated a sensitivity of 0.0156 μA/μM and a limit of detection of 5.3 μM for NADH detection.
Conclusions:
- Positively-charged, hierarchical PEDOT CMs electrodes offer superior performance for NADH detection compared to conventional PEDOT:PSS.
- The enhanced analytical performance provides a foundation for applications in biosensing, bio-fuel cells, and biocatalysis.
- This work highlights the potential of tailored PEDOT nanostructures for advanced electrochemical applications.
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