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Updated: Feb 5, 2026
07:34
Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
Published on: May 12, 2023
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Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
Perla P Argentato1, Helena de Cássia César2, Débora Estadella2
11Programa de Pós Graduação em Alimentos Nutrição e Saúde,Universidade Federal de São Paulo (UNIFESP),Santos,São Paulo,Brazil.
The British Journal of Nutrition
|September 5, 2018
Summary
Maternal diet during pregnancy and lactation influences offspring
Area of Science:
- Metabolic research
- Nutritional science
- Developmental biology
Background:
- Brown adipose tissue (BAT) plays a key role in thermogenesis and energy expenditure, making it a target for obesity research.
- Maternal nutrition during pregnancy and lactation impacts offspring's metabolic health, including BAT development.
- Limited research exists on the specific effects of maternal dietary fatty acids on fetal and postnatal BAT development.
Purpose of the Study:
- To investigate the role of maternal nutrition, specifically fatty acid composition, on brown adipose tissue (BAT) development and function.
- To explore the potential of nutritional interventions during gestation and lactation for preventing offspring obesity.
- To understand the epigenetic mechanisms linking maternal diet to BAT programming.
Main Methods:
- Review of existing literature on maternal nutrition, BAT development, and thermogenesis.
- Analysis of the impact of different fatty acids on uncoupling protein 1 (UCP-1) activation.
- Exploration of potential epigenetic modifications influenced by maternal dietary fat intake.
Main Results:
- Brown adipose tissue (BAT) activation via uncoupling protein 1 (UCP-1) is crucial for thermogenesis and is influenced by diet.
- Maternal nutritional status, particularly fatty acid intake, during critical developmental periods can program offspring's BAT.
- Specific dietary fatty acid modifications may offer a strategy for preventing metabolic diseases like obesity.
Conclusions:
- Modifying maternal dietary fatty acids during pregnancy and lactation is a promising strategy for preventing offspring obesity.
- Further research is needed to elucidate the precise mechanisms by which lipids program BAT.
- Understanding nutritional impacts on epigenetic regulation of BAT can inform preventive strategies for metabolic disorders.
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