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Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
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ER-phagy at a glance.

Paolo Grumati1, Ivan Dikic2,3, Alexandra Stolz3

  • 1Institute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, 60590 Frankfurt am Main, Germany.

Journal of Cell Science
|September 5, 2018
PubMed
Summary
This summary is machine-generated.

Selective autophagy, or ER-phagy, clears damaged endoplasmic reticulum (ER) via specific receptors. Different receptors handle distinct ER regions and stress responses, ensuring cellular quality control.

Keywords:
AutophagyCCPG1Endoplasmic reticulumFAM134BRTN3SEC62

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Autophagy Research

Background:

  • Selective autophagy is a key cellular quality control process.
  • Endoplasmic reticulum (ER) turnover occurs via ER-phagy, degrading ER components.
  • ER-resident proteins binding to Atg8 proteins mediate selective ER elimination.

Purpose of the Study:

  • To summarize recent findings on ER-phagy.
  • To highlight the roles of different ER-phagy receptors.
  • To discuss ER-phagy in yeast and mammalian cells.

Main Methods:

  • Review of recent literature on ER-phagy.
  • Analysis of ER-resident proteins involved in ER-phagy.
  • Comparison of ER-phagy mechanisms across different organisms.

Main Results:

  • ER-phagy utilizes distinct receptors for different ER subdomains and stresses.
  • Reticulon proteins (FAM134B/RETREG1, RTN3) remodel ER for basal turnover.
  • Transmembrane receptors (SEC62, CCPG1) respond to ER stress signals.

Conclusions:

  • ER-phagy is a complex process involving task-sharing receptors.
  • Receptor diversity reflects the ER's complex functions and morphology.
  • Understanding ER-phagy is crucial for cellular quality control mechanisms.