Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Genetics of Speciation02:16

Genetics of Speciation

21.7K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.7K
Adrenergic Receptors: ɑ Subtype01:31

Adrenergic Receptors: ɑ Subtype

3.0K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
3.0K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

3.8K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.8K
What is Population Genetics?01:25

What is Population Genetics?

64.8K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Epigenetic Markers for Precision Medicine.

Methods in molecular biology (Clifton, N.J.)·2018
Same author

MicroRNAs Role in Prostate Cancer.

Methods in molecular biology (Clifton, N.J.)·2018
Same author

Alcohol-Induced Epigenetic Changes in Cancer.

Methods in molecular biology (Clifton, N.J.)·2018
Same author

Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling.

Oncotarget·2016
Same author

Genetic variation in one-carbon metabolism in relation to genome-wide DNA methylation in breast tissue from heathy women.

Carcinogenesis·2016
Same author

Racial differences in genome-wide methylation profiling and gene expression in breast tissues from healthy women.

Epigenetics·2015

Related Experiment Video

Updated: Feb 5, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.1K

Interplay Between Genetic and Epigenetic Changes in Breast Cancer Subtypes.

Ramona G Dumitrescu1

  • 1Kelly Government Solutions, Bethesda, MD, USA. dumiragi30@yahoo.com.

Methods in Molecular Biology (Clifton, N.J.)
|September 5, 2018
PubMed
Summary

Genetic and epigenetic changes drive breast cancer development and progression. Understanding these molecular alterations across subtypes is crucial for precise diagnosis and personalized breast cancer treatment.

Keywords:
Basal-like and normal-like breast cancer subtypesBreast cancerERBB2/HER2-enrichedEpigenetic changesEpigenome studiesGenetic mutationsLuminal ALuminal BPrecision medicine

More Related Videos

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.3K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.6K

Related Experiment Videos

Last Updated: Feb 5, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.1K
ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.3K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.6K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading cause of cancer mortality in women.
  • Genetic mutations and epigenetic aberrations are key drivers of breast cancer.
  • High-throughput technologies have advanced understanding of molecular changes.

Purpose of the Study:

  • To discuss genetic and epigenetic modifications in distinct breast cancer subtypes.
  • To highlight the role of epigenome studies in further stratifying breast cancer.
  • To emphasize the importance of integrating genetic and epigenetic data for precision medicine.

Main Methods:

  • Review of recent high-throughput technology findings.
  • Analysis of genetic and epigenetic alterations in luminal A, luminal B, ERBB2/HER2-enriched, basal-like, and normal-like subtypes.
  • Examination of epigenome studies for breast cancer stratification.

Main Results:

  • Identification of distinctive genetic and epigenetic modifications across breast cancer subtypes.
  • Epigenome studies offer further stratification possibilities for breast cancer.
  • Genetic and epigenetic profiles vary significantly among different molecular subtypes.

Conclusions:

  • Genetic and epigenetic changes are fundamental to breast cancer.
  • Further stratification of breast cancer subtypes is achievable through epigenome studies.
  • Integrating genetic and epigenetic data is essential for advancing precision medicine in breast cancer care.