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Updated: Feb 5, 2026

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
Published on: October 26, 2009
Fast-forming BMSC-encapsulating hydrogels through bioorthogonal reaction for osteogenic differentiation
Yajie Zhang1, Hong Chen, Tingting Zhang
1CAS Key Laboratory for Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China. rjpei2011@sinano.ac.cn mliu2010@sinano.ac.cn.
Abstract:
An injectable in situ fast-forming hydrogel was easily fabricated through the inverse electron demand Diels-Alder click reaction between trans-cyclooctene and tetrazine. This hydrogel system simultaneously encapsulated bone morphogenetic protein-2 and BMSCs which showed potential applications in 3D bio-printing and tissue engineering.
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