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Interaction of nanodiamonds with bacteria
S Y Ong1, R J J van Harmelen, N Norouzi
1University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Gronigen, The Netherlands. romana.schirhagl@gmail.com.
Nanoscale
|September 6, 2018
Summary
Milled nanodiamonds show antibacterial properties against Gram-positive bacteria like S. aureus, but not Gram-negative E. coli. Their effectiveness depends on factors like concentration and size.
Area of Science:
- Materials Science
- Nanotechnology
- Microbiology
Background:
- Nanocarbons are engineered for biocompatible and antibacterial materials.
- Diamond nanoparticles exhibit biocompatibility and reduce bacterial viability.
- Nitrogen-vacancy (NV) centers in nanodiamonds offer sensing potential.
Purpose of the Study:
- To investigate the interaction of milled High-Pressure High-Temperature (HPHT) nanodiamonds with bacteria.
- To assess the antibacterial effects of nanodiamonds on Gram-positive and Gram-negative bacteria.
- To explore the factors influencing nanodiamond-bacteria interactions.
Main Methods:
- Exposure of S. aureus and E. coli to partially oxidized monocrystalline nanodiamonds.
- Assessment of bacterial colony-forming ability.
- Electron microscopy and confocal microscopy for interaction studies.
Main Results:
- Nanodiamonds significantly reduced S. aureus colony-forming ability.
- No significant adverse effects were observed on E. coli.
- Interaction effects depend on nanodiamond concentration, size, medium, and incubation time.
Conclusions:
- Milled HPHT nanodiamonds possess selective antibacterial activity against Gram-positive bacteria.
- Further research is needed to optimize nanodiamond properties for antibacterial applications.
- Nanodiamonds show potential for developing novel antibacterial materials.
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