Related Experiment Video
Updated: Feb 5, 2026
11:39
Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
Published on: June 9, 2019
9.7K
A Metabolomics Approach to Pharmacotherapy Personalization
Elena E Balashova1, Dmitry L Maslov2, Petr G Lokhov3
1Institute of Biomedical Chemistry, Pogodinskaya St. 10, Moscow 119121, Russia. balashlen@mail.ru.
Journal of Personalized Medicine
|September 8, 2018
Summary
Personalized medicine uses metabolomics to tailor drug therapy. Analyzing pre- and post-dose metabolite profiles predicts treatment effectiveness and monitors patient response for optimized outcomes.
Area of Science:
- Biochemistry
- Pharmacology
- Genomics
Background:
- Personalized medicine aims to optimize drug therapy based on individual patient characteristics.
- Omics technologies, particularly metabolomics, offer promising avenues for achieving this personalization.
Purpose of the Study:
- To review the application of metabolomics in personalizing drug therapy.
- To compare pharmacometabolomics with other pharmacotherapy personalization approaches.
Main Methods:
- Analysis of pre-dose and post-dose metabolite profiles in biofluids.
- Comparative description of pharmacogenomics, pharmacoproteomics, therapeutic drug monitoring, and pharmacometabolomics.
Main Results:
- Pre-dose metabolite profiles can predict individual drug treatment effectiveness.
- Post-dose metabolite profiles can evaluate drug efficacy, host response, and therapy outcomes.
Conclusions:
- Pharmacometabolomics, through metabolite profile analysis, is a valuable tool for personalizing drug therapy.
- Metabolite profiling offers a comprehensive approach to optimizing treatment strategies and patient outcomes.
Keywords:
mass spectrometrymetabolomicspersonalized medicinepharmacogenomicspharmacometabolomicstherapeutic drug monitoringMore Related Videos
Related Concept Videos
01:28Maslow's Humanistic Approach on Personality
1.1K
Abraham Maslow, a prominent figure in humanistic psychology, developed a theory centered on self-actualization, which he placed at the top of his hierarchy of needs. According to Maslow, self-actualization represents achieving one's full potential and is a rare accomplishment attained by approximately 2% of the population. Maslow identified notable historical figures such as Thomas Jefferson, Mahatma Gandhi, Helen Keller, and Martin Luther King Jr. as examples of self-actualized...
1.1K
01:26Psychosis: Goals of Pharmacotherapy
539
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
539
01:15Diabetes: Management and Pharmacotherapy
1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
01:25Personal Identity
386
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
386
01:27Psychodynamic Perspectives on Personality
1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
Psychodynamic theorists argue that unconscious...
1.6K
01:22Self-Report Tests of Personality
871
Self-report inventories are objective personality assessments that use multiple-choice items or numbered scales, typically ranging from 1 (strongly disagree) to 5 (strongly agree). They are often called Likert scales after Rensis Likert. These inventories are widely used due to their ease of administration and cost-effectiveness. One of the most prominent examples is the Minnesota Multiphasic Personality Inventory (MMPI), initially developed in the 1940s to assess abnormal personality traits.
871