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Updated: Feb 5, 2026
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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
Published on: August 1, 2017
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The Bone Marrow Microenvironment in Waldenström Macroglobulinemia
Shahrzad Jalali1, Stephen M Ansell1
1Division of Hematology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Hematology/Oncology Clinics of North America
|September 8, 2018
Summary
Waldenström macroglobulinemia (WM) involves B-cell lymphoma cells in the bone marrow (BM) producing excess immunoglobulin M (IgM). The BM microenvironment enhances malignant cell growth and IgM secretion in this indolent lymphoma.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoma.
- WM is characterized by lymphoplasmacytic cell infiltration of the bone marrow (BM).
- Increased production of monoclonal immunoglobulin M (IgM) by malignant cells is a hallmark of WM.
Purpose of the Study:
- To review the interaction between WM cells and the BM microenvironment.
- To elucidate how the BM microenvironment promotes malignant cell growth in WM.
- To discuss the mechanisms by which the BM microenvironment enhances IgM production in WM.
Main Methods:
- Literature review of available data on WM and BM microenvironment interactions.
- Analysis of cellular and noncellular components of the BM microenvironment in WM.
- Synthesis of information on cytokine-mediated enhancement of IgM secretion.
Main Results:
- WM cells interact extensively with both cellular and noncellular components of the BM.
- The BM microenvironment provides signals that promote the survival and proliferation of WM cells.
- Cytokines within the BM microenvironment significantly enhance IgM production by lymphoplasmacytic cells.
Conclusions:
- The BM microenvironment plays a critical role in the pathogenesis of Waldenström macroglobulinemia.
- Understanding these interactions is crucial for developing targeted therapies for WM.
- Targeting the BM microenvironment may offer a novel therapeutic strategy for WM.
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