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Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Monoclonal Antibodies for Waldenström Macroglobulinemia
Andres Dominguez1, Efstathios Kastritis2, Jorge J Castillo3
1Department of Internal Medicine, Fundación Valle del Lili, CES University, Cali, Colombia.
Abstract:
For the last 2 decades, anti-CD20 monoclonal antibodies have revolutionized the treatment of patients with B-cell lymphomas. These agents have shown efficacy when used as single agents and also have improved response and survival rates when added to chemotherapy. Monoclonal antibodies are safe and effective as well in patients with Waldenström macroglobulinemia (WM). The purpose of this article is to review the mechanism of action of monoclonal antibodies and to discuss current clinical data supporting their use in patients with WM. This review focuses on retrospective and prospective studies and clinical trials on anti-CD20 antibodies, anti-CD38 antibody, and anti-CXCR4 antibody.
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