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Fluorine-18: an untapped resource in inorganic chemistry
Cassis Varlow1, Daniel Szames, Kenneth Dahl
1Azrieli Centre for Neuro-Radiochemistry, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St. Toronto, ON M5T-1R8, Canada. neil.vasdev@utoronto.ca.
Abstract:
Advances in the field of fluorine chemistry have been applied extensively to the syntheses of 18F-labelled organic compounds and radiopharmaceuticals. However, 18F has sparely been used as a tool to explore inorganic chemistry and can be viewed as a research area worthy of further development. This review highlights the application of 18F in development of inorganic fluorinating agents, mechanistic studies and imaging tools.
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