Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Heart Rates01:31

Regulation of Heart Rates

3.9K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
3.9K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.1K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.1K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.3K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.3K
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

4.4K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
4.4K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

1.0K
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infarct-Limiting Efficacy of the μ<sub>2</sub>‑Opioid Receptor Peptide Agonist Endomorphin‑1 in Metabolic Syndrome and Aging.

Bulletin of experimental biology and medicine·2026
Same author

Cardioprotective Effect of Endomorphin-1 In Vitro: the Role of Intracellular Messengers.

Bulletin of experimental biology and medicine·2026
Same author

Relationship between Myocardial Adaptive Resistance to Ischemia/Reperfusion and Leptin Receptor Expression in Rats with Metabolic Syndrome.

Bulletin of experimental biology and medicine·2026
Same author

Dynamics of Endogenous Somatostatin and the Infarct-Limiting Effect of Octreotide in a Rat Model of Long-Term Ischemia/Reperfusion.

Bulletin of experimental biology and medicine·2026
Same author

Infarct-Limiting Efficacy of K<sub>ATP</sub> Channel Activators and Nitric Oxide Donors under Conditions of Their Chronic Administration and Diet-Induced Metabolic Syndrome Conditions in Rats.

Bulletin of experimental biology and medicine·2025
Same author

Involvement of Receptor Apparatus in the Realization of Antinociceptive Activity of Songorine.

Bulletin of experimental biology and medicine·2025

Related Experiment Video

Updated: Feb 5, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.7K

[ROLE OF ENDOGENOUS OPIOID SYSTEM IN THE REGULATION OF FUNCTIONAL STATE OF HEART].

L N Maslov, A V Mukhomedzyanov, Yu B Lishmanov

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |September 8, 2018
    PubMed
    Summary

    Opioid peptides affect cardiovascular function through opioid receptors on heart cells, nerves, and adrenal glands. Central opioid receptors in the brain also influence these cardiovascular effects.

    More Related Videos

    Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
    07:49

    Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

    Published on: July 21, 2023

    2.0K
    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
    08:54

    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

    Published on: March 29, 2019

    7.6K

    Related Experiment Videos

    Last Updated: Feb 5, 2026

    Myocardial Infarction and Functional Outcome Assessment in Pigs
    12:03

    Myocardial Infarction and Functional Outcome Assessment in Pigs

    Published on: April 25, 2014

    28.7K
    Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
    07:49

    Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

    Published on: July 21, 2023

    2.0K
    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
    08:54

    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

    Published on: March 29, 2019

    7.6K

    Area of Science:

    • Cardiovascular Physiology
    • Neuropharmacology
    • Endocrinology

    Background:

    • Opioid peptides are known to influence various physiological systems.
    • The cardiovascular system is a potential target for opioid peptide actions.
    • Understanding the mechanisms of opioid effects on the heart is crucial for therapeutic applications.

    Purpose of the Study:

    • To elucidate the mechanisms underlying the cardiovascular effects of opioid peptides.
    • To identify the specific opioid receptor locations involved in these effects.
    • To differentiate between central and peripheral actions of opioids on cardiovascular function.

    Main Methods:

    • The study likely involved investigating the distribution and activation of opioid receptors in cardiovascular tissues and the central nervous system.
    • Pharmacological interventions targeting opioid receptors may have been employed.
    • Cardiovascular parameters were likely monitored to assess the effects of opioid administration.

    Main Results:

    • Opioid receptors are present on cardiomyocytes, ICA, and endothelial cells, suggesting direct cardiac effects.
    • Opioid receptors are also found on sympathetic and parasympathetic nerve terminals in the heart and adrenal glands, indicating neural and hormonal influences.
    • Opioids crossing the blood-brain barrier exert cardiovascular effects via central opioid receptors.

    Conclusions:

    • Cardiovascular effects of opioid peptides are mediated by both peripheral and central opioid receptors.
    • Peripheral actions involve direct effects on cardiac cells and modulation of autonomic nerves and adrenal function.
    • Central actions through the blood-brain barrier contribute significantly to the overall cardiovascular response to opioids.