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Updated: Feb 5, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
Published on: April 19, 2015
Quantitative approaches of nanofibers organization for biomedical patterned nanofibrous scaffold by image analysis
Neda Shah Hosseini1, Bertrand Simon2, Tahani Messaoud3
1Laboratoire de Physique et Mécanique Textiles EA 4365-UHA Mulhouse, Mulhouse, France.
Abstract:
This study proposes a novel design of a laboratory built static collector using the 3D printing technology. This new collector produces aligned-to-random nanofibers in nanofibrous scaffold through electrospinning process. A design of experiment (DOE), based on response surface, analyzes the effect of the main process parameters; concentration, voltage, and distance; on the responses diameter and orientation. A quantifying approach has been used to investigate the orientation of nanofibers in the produced patterned scaffold through Fourier transforms method. The obtained results have proven a good potential to be used in tissue engineering application, especially for cells requiring specific guidance. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2963-2972, 2018.
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