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Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
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Functionalized glycolipids for potential bioconjugation of vesicles
Mojtaba Tabandeh1, Ean Wai Goh1, Abbas Abdulameer Salman2
1Chemistry Department, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Carbohydrate Research
|September 10, 2018
Summary
Two novel glycolipids were synthesized. One shows promise for targeted drug delivery, while the other
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Drug Delivery Systems
Background:
- Glycolipids are amphiphilic molecules with diverse biological roles.
- Oligoethylene oxide linkers are used to modify surfactant properties.
- Azide functional groups allow for further chemical modification.
Purpose of the Study:
- To synthesize azide-terminated glycolipids with oligoethylene oxide spacers.
- To investigate the self-assembly behavior of these novel glycolipids.
- To compare their assembly properties with non-spaced base surfactants.
Main Methods:
- Chemical synthesis of two azide-terminated glycolipids.
- Characterization of synthesized compounds.
- Study of self-assembly behavior in solution.
- Comparison with base surfactant properties.
Main Results:
- Successful synthesis of two azide-terminated oligoethylene oxide spacered glycolipids.
- Guerbet lactoside-based glycolipid exhibits potential for targeted drug delivery.
- Ethylene oxide linker coiling in the glucoside derivative hinders its application.
Conclusions:
- The structural characteristics of the linker significantly influence glycolipid assembly and application.
- Guerbet lactoside-based glycolipids are promising candidates for drug delivery applications.
- Glucoside-based glycolipids with coiled linkers are less suitable for such applications.
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