Cross-talks between the kidneys and the central nervous system in multiple sclerosis

Area of Science:

• Neuroimmunology
• Nephrology
• Autoimmune Diseases

Background:

• Multiple sclerosis (MS) is a common inflammatory demyelinating autoimmune disorder affecting young adults.
• Emerging evidence highlights the role of non-neural tissue impairment in MS pathology.
• The central nervous system (CNS) and kidneys share bidirectional relationships, metabolic activities, and functional similarities.

Purpose of the Study:

• To investigate the potential influence of kidney function on the initiation, progression, or amelioration of multiple sclerosis.
• To explore the CNS-kidney axis as a potential therapeutic target for MS.

Main Methods:

• This study proposes a hypothesis based on existing evidence regarding the CNS-kidney relationship.
• Analysis of hormonal and non-hormonal interactions between the CNS and kidneys in the context of MS.

Main Results:

• The functional and hormonal interplay between the CNS and kidneys suggests a significant role for renal function in MS.
• CNS impairment in MS patients may trigger responses in the kidneys.

Conclusions:

• Kidneys may exert a considerable effect on multiple sclerosis.
• Targeting kidney function could represent a future therapeutic avenue for managing MS.